Proteomics for Biological Discovery

"Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics.

Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications
Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications
Discusses higher level integrative aspects, including technical challenges and applications for drug discovery
Accessible to the novice while providing experienced investigators essential information

Proteomics for Biological Discovery is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics. "

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Title of ebook: Proteomics for Biological Discovery
ISBN: 9780470007730
parent-ISBN: 9780471160052
Publisher: Wiley-Liss
Internet download file size: 12025 kb
Pages: 344
Published: 06-2006
Released online for download: 06-12-2006
Author of eBook: Veenstra, Timothy D.
Author of eBook: Yates, John R.

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05-2

Chapter One

Mass Spectrometry: The Foundation of Proteomics

Timothy D. Veenstra Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland

1.1 INTRODUCTION

Scientific direction can be driven by many factors. Obviously, science is still primarily hypothesis driven; however, the continuing technology developments have enabled a greater focus on discovery driven science. Hypothesis driven science formulates a question and then uses whatever technology is available to acquire the information necessary to answer that question. In contrast, discovery driven science collects the information first and then determines the questions (or answers) that can be formulated from the available data. While it may seem to function through a "shot-in-the-dark" mentality, present technological developments make discov ... read full excerpt from Proteomics for Biological Discovery ebook

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