Chromatographic Methods in Clinical Chemistry and Toxicology
Chapter One
Quality Assurance, Quality
Control and Method Validation
in Chromatographic Applications
Michele L. Merves and Bruce A. Goldberger
University of Florida, College of Medicine, Department of Pathology, Immunology and Laboratory
Medicine, P.O. Box 100275, Gainesville, FL 32610-0275, USA
1.1 INTRODUCTION
Clinical chemistry and toxicology are also known as clinical biochemistry or clinical
pathology, and they utilize a variety of analytical procedures to analyze body fluids to aid
in medical prevention, diagnosis and treatment. Analytes commonly targeted include
electrolytes, creatinine, albumin and other proteins, iron and prescription (therapeutic) and
illicit drugs.
The focus of this chapter is on quality assurance and quality control issues facing clinical
laboratories, with emphasis on chromatographic analysis. Chromatography is a versatile
analytical technique with diverse applications including gas chromatography (GC), liquid
chromatography (LC), GC or LC coupled with ma ... read full excerpt from Chromatographic Methods in Clinical Chemistry and Toxicology ebook
