81-1
Chapter One
Qualitative Knowledge Models in
Functional Genomics and
Proteomics
MOR PELEG, IRENE S. GABASHVILI, and RUSS B. ALTMAN
1.1. INTRODUCTION
Predicting pathological phenotypes based on genetic mutations remains a
fundamental and unsolved issue. When a gene is mutated, the molecular functionality
of the gene product may be affected and many cellular processes may go
awry. Basic molecular functions occur in networks of interactions and events that
produce subsequent cellular and physiological functions. Most knowledge of
these interactions is represented diffusely in the published literature, Excel lists,
and specialized relational databases and so it is difficult to assess our state of understanding
at any moment. Thus it would be very useful to systematically store knowledge
in data structures that allow the knowledge to be evaluated and examined in
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