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Home > Medical > Medical General & Other > Stem Cells: Nuclear Reprogramming and Therapeutic Applications, Number 265
Stem Cells: Nuclear Reprogramming and Therapeutic Applications, Number 265
by Foundation Symposium, Novartis
 
 
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Stem Cells: Nuclear Reprogramming and Therapeutic Applications, Number 265
This book focuses on the factors that maintain stem cells in a pluripontent state or drive them to create differentiated and lineage-committed cells in vitro and in vivo Gives a comprehensive overview of current issues in stem cell research Unites a general consideration of stem cell research with a specific concentration on the key issue of nuclear reprogramming Discusses important ethical and policy issues which create the framework within which scientists carry out stem cell research Contributions from leading figures in the field


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Title of ebook: Stem Cells: Nuclear Reprogramming and Therapeutic Applications, Number 265
ISBN: 9780470091449
parent-ISBN: 9780470091432
Publisher: John Wiley & Sons, Ltd.
Internet download file size: 2272 kb
Pages: 230
Published: 09-2005
Released online for download: 09-01-2005
Author of eBook: Novartis Foundation Symposium
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Chapter One

Chair's introduction

John Gearhart

Department of Gynaecology and Obstetrics, The Johns Hopkins School of Medicine, Baltimore, MD21287, USA

In my introduction I would like to frame some of the questions that we will be addressing over the next several days. Some of these are obvious, but I hope that out of this meeting we will synthesize some new ones.

Clearly, we would like to know what stem cells are, and how we can define them functionally and molecularly. What are their properties? What is this entity known as 'stemness' that has now appeared in the literature? Are we talking about epigenetics or chromatin structure? All of these are likely to be involved. What are the sources of stem cells? In fetal tissues, embryonic tissues, adult tissues, how do we recognize, isolate, characterize and grow them? These are all issues that will be central to our discussions over the next three days. Most importantly, we are concerned about how we can control these cells in the laboratory. How do we get them to do the things that we want them to do, such as differentiating into specific cell types with high efficiency? What strategies are currently used and how successful are these? In grafts, can we get stem cells or their derivatives to do what we want th ... read full excerpt from Stem Cells: Nuclear Reprogramming and Therapeutic Applications, Number 265 ebook



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