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Home > Science & Nature > Chemistry > Chemistry - Industrial & Technical > Vaccine Adjuvants and Delivery Systems
Vaccine Adjuvants and Delivery Systems
 
 
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Vaccine Adjuvants and Delivery Systems

The authoritative reference on recent developments in vaccinology

New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems:

  • Provides a comprehensive overview of the rapidly evolving field and developing formulation methods
  • Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage

  • Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more

  • Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions

  • Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants

A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.



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Title of ebook: Vaccine Adjuvants and Delivery Systems
ISBN: 9780470134924
parent-ISBN: 9780471739074
Publisher: Wiley-Interscience
Internet download file size: 5080 kb
Pages: 470
Published: 06-2007
Released online for download: 06-15-2007
Editor: Singh, Manmohan
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07-4

Chapter One

DEVELOPMENT OF VACCINE ADJUVANTS: A HISTORICAL PERSPECTIVE

Gary Ott and Gary Van Nest

1.1 INTRODUCTION

Since the earliest attempts to raise significant immune responses against nonliving agents, investigators have tried to identify useful additives that can be combined with antigens to enhance immune responses. Such immune-enhancing additives are known as adjuvants. Virtually all adjuvant systems developed to date have focused on one of two mechanisms: specific immune activation or the delivery-depot effect. Although many adjuvant systems have been developed and tested in preclinical models, few have actually proved useful for human vaccines. The primary limitations for the use of new adjuvant systems with human vaccines revolve around safety issues. Whereas the toxicity of adjuvants has been reduced systematically through research and development efforts over the last 80 years, the safety barriers presented by regulatory and liability issues have continued to increase. Adjuvants to be used with prophylactic vaccines in normal, healthy populations need to have virtually pristine safety pro ... read full excerpt from Vaccine Adjuvants and Delivery Systems ebook



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