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Chapter One
CANCER VACCINES:
PROGRESS AND PROMISE
Rimas J. Orentas, Bryon Johnson, and James Hodge
1.1 INTRODUCTION
The increasingly sophisticated understanding that we have of how tumors and the
immune system coevolve in the host is leading to a steady stream of new ways
to apply this knowledge through the design of cancer vaccines. The rapidity with
which these vaccine approaches can in some cases be translated into a clinical
trial is a testimony to the years of fundamental medical research that has given
rise to the current fields of bone marrow transplantation, adoptive immunotherapy,
antibody therapy, and experimental vaccine development. As the science of cancer
vaccines has advanced, so has a panoply of regulatory and institutional hurdles that
seems to threaten the use of these therapeutic advances, ... read full excerpt from Cancer Vaccines and Tumor Immunity ebook
