This book gives the professional pharmaceutical scientist a basic and comprehensive tool to facilitate the preclinical development process by bringing together an overview of the preclinical process and a compendium of methods and techniques that need to be considered when developing a new drug. The book details steps in the preclinical process including: prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modelling, and regulations. It includes problems that are encountered, solutions to these problems, and limitations of various methods and techniques used in determining the safety and efficacy of a drug at this stage.