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Chapter One
ACCURATE MASS
MEASUREMENTS WITH
ORTHOGONAL AXIS TIME-OF-FLIGHT
MASS SPECTROMETRY
John C. Fjeldsted
Director, Research and Development, LC/MS Division, Agilent Technologies, Inc.,
Santa Clara, California
AN APPEALING attribute of time-of-flight mass spectrometry is its fundamental
simplicity. It is easy to conceptualize that for a given population of ions all
accelerated to the same energy those with the lightest mass will travel with a greater
velocity and reach an end point sooner. Simply recording these arrival times and
providing a calibration function converts ion arrival times to mass values and produces
a simple spectrum.
From simple beginnings time-of-flight has transformed itself into a very powerful
analytical tool. The success of orthogonal axis time-of-flight mass spectrometry
is the result of both fundamental improvements in analyzer geometry ... read full excerpt from Liquid Chromatography Time-of-Flight Mass Spectrometry ebook
