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Home > Medical > Neuroscience > Glial Neurobiology-eBook
Glial Neurobiology
 
 
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Glial Neurobiology
AT LAST - A comprehensive, accessible textbook on glial neurobiology!

Glial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead, on neurones and neuronal networks because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn’t exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease.

Authored by leading experts in the field, Glial Neurobiology  provides a concise, authoritative introduction to glial physiology and pathology.

The book presents all major types of glial pathology; topics include: the morphology and interrelationships between glial cells and neurones in different parts of the nervous system; intra and inter cellular signaling in glial networks; the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system; cellular and molecular mechanisms of metabolic neuronal-glial interactions; and the role of glia in nervous system pathology.

  • Profoundly illustrated with figures, including unique images from the authors’ own libraries of images
  • Includes numerous text boxes to highlight and summarize key facts
  • Features an associated website

This textbook is invaluable to undergraduate and postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, neurology, neurosurgery, and physiology students. Furthermore, this title is of interest to professionals and researchers in neuroscience, physiology, pharmacology and pharmaceutics.



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Title of ebook: Glial Neurobiology
ISBN: 9780470513071
Publisher: Wiley-Interscience
Internet download file size: 9322 kb
Pages: 230
Released online for download: 08-20-2007
Author of eBook: Verkhratsky, Alexei
Author: Butt, Arthur

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Glial Neurobiology


Chapter One

Introduction to Glia

There are two major classes of cells in the brain - neurones and glia (Figure 1.1). The fundamental difference between these lies in their electrical excitability - neurones are electrically excitable cells whereas glia represent nonexcitable neural cells. Neurones are able to respond to external stimulation by generation of a plasmalemmal 'all-or-none' action potential, capable of propagating through the neuronal network, although not all neurones generate action potentials. Glia are unable to generate an action potential in their plasma membrane (although they are able to express voltage-gated channels). Glial cells are populous (as they account for ~90 per cent of all cells in the human brain) and diverse. In the central nervous system (CNS) they are represented by three types of cells of neural (i.e. ectodermal) origin, often referred to as 'macroglial cells' (which may also be properly called 'neuroglial cells'). These are the astrocytes, the oligodendrocytes and the ependymal cells. The ependymal cells ... read full excerpt from Glial Neurobiology ebook



 


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