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Home > Science & Nature > Chemistry > Chemistry - Industrial & Technical > Fundamentals of Analytical Toxicology-eBook
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Fundamentals of Analytical Toxicology
The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens.

After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electro­phoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results.

  • A clearly written, practical, integrated approach to the basics of analytical toxicology.
  • Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications.
  • Assumes only a basic knowledge of analytical chemistry.
  • An accompanying website provides additional material and links to related sites.

Written by an experienced team of authors, Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. 

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Title of ebook: Fundamentals of Analytical Toxicology
ISBN: 9780470516287
Publisher: John Wiley & Sons, Ltd.
Internet download file size: 4472 kb
Pages: 544
Released online for download: 06-02-2008
Author of eBook: Flanagan, Robert J.
Author: Taylor, Andrew A.
Author of eBook: Watson, Ian D.

Fundamentals of Analytical Toxicology


Chapter One

Analytical Toxicology: Overview

1.1 Introduction

Analytical toxicology is concerned with the detection, identification and measurement of drugs and other foreign compounds (xenobiotics) and their metabolites in biological and related specimens. The analytical toxicologist can play a useful role in the diagnosis, management and, in some cases, the prevention of poisoning, but to do so a basic knowledge of clinical and forensic toxicology is essential. Moreover the analyst must be able to communicate effectively with clinicians, pathologists, coroners, police and, possibly, others. In addition, a good understanding of clinical chemistry, pharmacology and pharmacokinetics is desirable.

1.1.1 Historical development

The use of physicochemical techniques in the analysis of drugs and other poi ... read full excerpt from Fundamentals of Analytical Toxicology ebook



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