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Home > Medical > Medical General & Other > Bioinformatics for Vaccinology
Bioinformatics for Vaccinology
by Flower, Darren R.
 
 
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Bioinformatics for Vaccinology
Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. 

Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. 

This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by

  • introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology
  • putting it into a historical and societal context, and 
  • exploring the scope of its methods and applications.

Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.



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Title of ebook: Bioinformatics for Vaccinology
ISBN: 9780470699829
parent-ISBN: 9780470027110
Publisher: John Wiley & Sons, Ltd.
Internet download file size: 2851 kb
Pages: 312
Published: 12-2008
Released online for download: 12-19-2008
Author of eBook: Flower, Darren R.
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Bioinformatics for Vaccinology


Chapter One

Vaccines: Their Place in History

There is nothing new except what has been forgotten. -Marie Antoinette (1755-1793)

Smallpox in history

For the first hundred years or so, the story of vaccination was the story of smallpox. Smallpox first appeared in remote antiquity, perhaps 10 thousand years ago when humankind first embraced settled farming in preference to transhumance. It was, many say, the most feared of all ancient diseases: smallpox killed 20-30% of those who contracted it, disfiguring or blinding those that survived.

It has been suggested, primarily on the basis of extant historical evidence, that virulent smallpox did not appear in Europe until the early modern era - most probably during the seventeenth century - and gradually replaced an endemic and much less virulent form of the disease. This transition seems to have occurred during a series of erratic smallpox outbreaks during the fifteenth and sixteenth centuries. With more certainty we can say that smallpox's cas ... read full excerpt from Bioinformatics for Vaccinology ebook



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