Liquid Chromatographymass Spectrometry
An Introduction
Chapter One
Introduction
Learning Objectives
To understand the need to interface liquid chromatography and mass
spectrometry.
To understand the requirements of an interface between liquid chromatography
and mass spectrometry and the performance of the combined system.
The combination of chromatography and mass spectrometry (MS) is a subject
that has attracted much interest over the last forty years or so. The combination
of gas chromatography (GC) with mass spectrometry (GC-MS) was first
reported in 1958 and made available commercially in 1967. Since then, it has
become increasingly utilized and is probably the most widely used 'hyphenated'
or 'tandem' technique, as such combinations are often known. The acceptance
of GC-MS as a routine technique has in no small part been due to the fact th ... read full excerpt from Liquid Chromatography – Mass Spectrometry : An Introduction ebook
