Chapter One
FACTORS THAT IMPACT THE
DEVELOPABILITY OF DRUG
CANDIDATES: AN OVERVIEW
Chao Han
GlaxoSmithKline, Collegeville, PA 19426
Binghe Wang
Department of Chemistry, Georgia State University, Atlanta, GA 30303
1.1. Issues facing the pharmaceutical industry
1.2. Factors that impact developability
1.2.1. Commercial goal
1.2.2. The chemistry efforts
1.2.3. Target validation in animal models
1.2.4. Pharmacokinetics and drug metabolism
1.2.5. Preparation for pharmaceutical products
1.2.6. Remarks on developability criteria
1.3. Drug delivery factors that impact developability
References
1.1. ISSUES FACING THE PHARMACEUTICAL INDUSTRY
Drug discovery is a long, arduous, and expensive process. It was estimated that the
total expenditure for research and development in the U.S. pharmaceutical industries ... read full excerpt from Drug Delivery: Principles and Applications ebook
