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Natural Killer Cells
Imprint: Academic Press
Format: ePub Encrypted (DRM)
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The Natural Killer [NK] Cell plays a critical role in regulating the innate and adaptive immune response to pathogens, injury and stress. Although originally portrayed as primarily a lytic cell, the NK cell has emerged as a cell capable of helper function, expansion, contraction, and accelerated memory responses - features similar to other adaptive immune cells. It is a professional accelerator of immunity, mediating dendritic cell maturation and its precursors critical for the origin and development of secondary lymph node structures. NK cells also play an essential role in mammalian placentation by regulating the quality of blood supply to the growing fetus. These characteristics place the NK cell in a unique position, with a major role in sculpting the host response to damage and injury. This volume is the first complete and authoritative reference to explore these emergent, exciting aspects of the NK cell, placing it at the center of damage/danger recognition and the response to stress. Natural Killer Cells details NK cell biology, the role of NK cells in regulating immunity through interactions with other cells and tissues, the participation of NK cells in disease and special topics in NK biology.
- Provides a broad, detailed canvas for students, fellows, scientists, and practitioners
- Includes figures, histologic sections, and illustrations of the ontogeny of NK cells
- Image database included in companion website
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| Title of eBook: Natural Killer Cells | |
| Release Date: 12-14-2009 | |
| Publisher: Academic Press |
This eBook download is available in the following formats:
| Parent title | Natural Killer Cells |
|---|---|
| Encrypted (DRM) | Yes |
| SKU | 9780080919294 |
| File size | 14862 |
| Security | n/a |
| Printing | Not allowed |
| Copying | Not allowed |
| Read aloud | No Sys requirements Download reader |
| Devices | Samsung Tablet, Apple Ipad & Iphone, Barnes & Noble Nook, Kobo eReader, Aluratek Libre, Iliad, Nokia, Blackberry, Hanlin |
| Note | Excellent navigation features are available via Adobe such as bookmarks and a quick access table of contents. Text search is easily accessible. An Adobe DRM-protected file is different than a pdf file in that it uses Adobe DRM (Digital Rights Management) technology, which authors and publishers use to protect their content from illegal online distribution and to set certain privileges such as restrictions on copying and printing. |
Natural Killer Cells
Chapter One
Developmental stages and pathways of NK cell maturationBartosz Grzywacz, Jeffery S Miller, Michael R Verneris
CHAPTER CONTENTS
The early events in hematopoiesis 3
NK cells as a distinct cell type 4
Lineage specific growth factors 4
Sites of NK development: the importance of the developmental environment 5
Fate determining interactions with stroma 6
Transcription factors involved in NK cell differentiation 7
Second messenger signalling in NK cell development 10
The NK cell ontogeny-lessons from evolution 11
Lessons from embryogenesis 12
Lessons from NK cell immune reconstitution after hematopoietic cell transplantation 12
Stages of NK cell development 13
Acquisition of inhibitory receptors during NK cell development 14
Linear and branching models of human NK cell development 15
Boundaries of NK cell lineage 16
Summary 17
ABSTRACT
Hematopoietic stem cells (HSCs) by definition can differentiate into all types of blood cells. There are several factors and events that promote HSC differentiation into the natural killer (NK) cell lineage. These include soluble factors, with a prominent role for interleukin 15, as well as contact– or gradient-depen
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