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Neuroendocrinology
By: Luciano Martini , George ChrousosImprint: Elsevier Science
Format: ePub Encrypted (DRM)
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Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience.
Volumes 181 and 182 of Progress in Brain Research provide a rapid view of the major points presently discussed at biological and clinical levels.
The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques.
The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers (prostate, breast, etc,). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes).
. The best researchers in the field provide their conclusions in the context of the latest experimental results
. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
. Of great value for researchers and experts, but also for students as a background reference
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| Title of eBook: Neuroendocrinology | |
| Release Date: 07-07-2010 | |
| Publisher: Elsevier Science |
This eBook download is available in the following formats:
| Parent title | Neuroendocrinology |
|---|---|
| Encrypted (DRM) | Yes |
| SKU | 9780444537034 |
| File size | 9268 |
| Security | n/a |
| Printing | Not allowed |
| Copying | Not allowed |
| Read aloud | No Sys requirements Download reader |
| Devices | Samsung Tablet, Apple Ipad & Iphone, Barnes & Noble Nook, Kobo eReader, Aluratek Libre, Iliad, Nokia, Blackberry, Hanlin |
| Note | Excellent navigation features are available via Adobe such as bookmarks and a quick access table of contents. Text search is easily accessible. An Adobe DRM-protected file is different than a pdf file in that it uses Adobe DRM (Digital Rights Management) technology, which authors and publishers use to protect their content from illegal online distribution and to set certain privileges such as restrictions on copying and printing. |
Neuroendocrinology
Chapter One
Cellular signalling: peptide hormones and growth factorsBarry I. Posner and Stephane A. Laporte
Departments of Medicine and Cell Biology, McGill University, Montreal, Quebec, Canada
Abstract: Peptide hormones and growth factors initiate signalling by binding to and activating their cell surface receptors. The activated receptors interact with and modulate the activity of cell surface enzymes and adaptor proteins which entrain a series of reactions leading to metabolic and proliferative signals. Rapid internalization of ligand–receptor complexes into the endosomal system both prolongs and augments events initiated at the cell surface. In addition endocytosis brings activated receptors into contact with a wider range of substrates giving rise to unique signalling events critical for modulating proliferation and apoptosis. Within the endosomal system, receptor function is regulated by lowering vacuolar pH, augmenting ligand proteolysis and promoting receptor kinase dephosphorylation. Ubiquitination–deubiquitination plays a key role in regulating receptor traffic through the endosomal system resulting in either recycling to the cell surface or degradation in multivesicular–lysosomal elements. From a clinical perspective there are several studies showing that manipulating endosomal processes may constitute a new therapeutic strategy.
Keywords: growth factors; surface receptors; internalization of ligand–receptor complexes; endocytosis; ubiquitination–deubiquitination
Historical survey
The action of polypeptide h
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