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Rokita, S. E. Quinone Methides (Wiley Series of Reactive Intermediates in Chemistry and Biology #4) eBook

Quinone Methides (Wiley Series of Reactive Intermediates in Chemistry and Biology #4)

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eBook Publisher: John Wiley & Sons
Imprint: Wiley-Interscience

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Multidisciplinary perspectives and approaches to quinone methides research

The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective.

This inaugural volume in the series, Quinone Methides, represents the first book devoted to this fascinating and useful intermediate. The authors of this work reflect the many disciplines and approaches to quinone methides research. The volume therefore covers a broad range of topics, including theoretical treatments, generation and detection of intermediates, characterization and applications in chemistry and biochemistry, and biological reactivity. Among the chapters are:

Photochemical generation and characterization of quinone methides

Quinone methide stabilization by metal complexation

Self-immolative dendrimers based on quinone methides

Characterization of quinone methides by spectral global fitting and 13C labeling

Formation and reactions of xenobiotic quinone methides in biology

Quinone methides in lignification

With this collection of topics, readers already familiar with quinone methides have the opportunity to advance their own research by discovering new inspiration and opportunities in allied areas. Moreover, the range of topics and perspectives covered make this volume accessible to readers with a broad range of interests, including organic and physical chemistry, biochemistry, biotechnology, and pharmaceutics.

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Title of eBook: Quinone Methides (Wiley Series of Reactive Intermediates in Chemistry and Biology #4)
Release Date: 02-17-2009
Publisher: Wiley-Interscience

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Quinone Methides (Wiley Series of Reactive Intermediates in Chemistry and Biology #4)


Chapter One

PHOTOCHEMICAL GENERATION AND CHARACTERIZATION OF QUINONE METHIDES

Matthew Lukeman Department of Chemistry, Acadia University, Wolfville, Nova Scotia, Canada B4P 2R6

1.1 INTRODUCTION

Quinone methides (QMs) are reactive intermediates that are commonly encountered in many areas of chemistry and biology. Quinone methides contain a cyclohexadiene core with a carbonyl and a methylene unit attached and are related to quinones, which have two carbonyl groups, and quinone dimethides, which have two methylene groups. Quinone methides are highly polar and are much more reactive than their relatives. Ortho (1) and para (2) quinone methides are the most commonly encountered isomers, although meta-quinone methides (3), which are non-Kekul

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