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Galectins
By: Anatole A. Klyosov , Zbigniew J. WitczakeBook Publisher: John Wiley & Sons
Imprint: John Wiley & Sons, Inc.
Format: Adobe Encrypted (DRM)
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The comprehensive guide to the current understanding of galectins and their promising potential in drug design
This is the first book focusing on galectins. It was inspired by topics discussed at the symposium "Galectins: Structures, Functions, and Therapeutic Targets" that was a part of the 234th American Chemical Society meeting in 2007. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Galectins includes:
* An overview of early galectin research
* An explanation of the nature of galectins
* A discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cell
* An exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity
* A discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistance
* An introduction to new approaches to designing galectin inhibitors
This is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers.
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| Title of eBook: Galectins | |
| Release Date: 10-17-2008 | |
| Publisher: John Wiley & Sons, Inc. |
This eBook download is available in the following formats:
| Parent title | Galectins |
|---|---|
| Encrypted (DRM) | Yes |
| SKU | 9780470377789 |
| File size | 9943 |
| Security | n/a |
| Printing | Not allowed |
| Copying | Not allowed |
| Read aloud | No Sys requirements Download reader |
| Devices | Samsung Tablet, Apple Ipad & Iphone, Barnes & Noble Nook, Kobo eReader, Aluratek Libre, Iliad, Nokia, Blackberry, Hanlin |
| Note | Excellent navigation features are available via Adobe such as bookmarks and a quick access table of contents. Text search is easily accessible. An Adobe DRM-protected file is different than a pdf file in that it uses Adobe DRM (Digital Rights Management) technology, which authors and publishers use to protect their content from illegal online distribution and to set certain privileges such as restrictions on copying and printing. |
Galectins
Chapter One
STUMBLING ON GALECTINSSamuel H. Barondes Center for Neurobiology and Psychiatry, UCSF, 401 Parnassus Ave, San Francisco, CA 94143-0984, USA
INTRODUCTION
This symposium about galectins has given me the opportunity to look back on the early research that led to their discovery and to take pleasure in reviewing the many fascinating developments since I moved on to other things. My interest in carbohydrate-binding proteins grew out of speculations about the possible role of protein-glycoconjugate interactions in the formation of specific synaptic connections in the brain, which explains how I-a psychiatrist and neuroscientist-stumbled into this field.
I first became aware of the potential biological importance of protein-glycoconjugate interactions in conversations with Victor Ginsburg, whom I met in 1961 at the National Institutes of Health in Bethesda, Maryland. I was, at the time, a post-doctoral fellow in Marshall Nirenbergs's lab and had the good fortune to participate in his studies of synthetic polynucleotides and the genetic code that soon brought him a Nobel prize. Vic, who was in the lab next door, was convinced that the next important code to solve was the one that determined how cells selectively adhere to each other to form complex tissues, and that protein-glycoconjugate interactions must play a role. He based his argument on the presence of complex glycoconjugates on cell surfaces and his hunch that their specific structures must have some biological significance. I found this idea very persuasive and tucked it away until I could explore it.
Over the next 10 years, I completed my clinical
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