Welcome,
New User!
New User!
Bacterial Population Genetics in Infectious Disease
eBook Publisher: John Wiley & Sons
Imprint: Wiley-Blackwell
Format: Adobe Encrypted (DRM)
Earn $0.50 - Write a Review »
Our Price
$119.99
Reward Money:
$0.00
This book is a unique synthesis of the major concepts and methods in bacterial population genetics in infectious disease, a field that is now about 35 yrs old. Emphasis is given to explaining population-level processes that shape genetic variation in bacterial populations and statistical methods of analysis of bacterial genetic data. A "how to" of bacterial population genetics, which covers an extremely large range of organisms Expanding area of science due to high-throughput genome sequencing of bacterial pathogens Covers both fundamental approaches to analyzing bacterial population structures with conceptual background in bacterial population biology Detailed treatment of statistical methods
Share your thoughts on the Bacterial Population Genetics in Infectious Disease Medical eBook with others!
| Title of eBook: Bacterial Population Genetics in Infectious Disease | |
| Release Date: 03-16-2010 | |
| Publisher: Wiley-Blackwell |
This eBook download is available in the following formats:
| Parent title | Bacterial Population Genetics in... |
|---|---|
| Encrypted (DRM) | Yes |
| SKU | 9780470600115 |
| File size | 9064 |
| Security | n/a |
| Printing | Not allowed |
| Copying | Not allowed |
| Read aloud | No Sys requirements Download reader |
| Devices | Samsung Tablet, Apple Ipad & Iphone, Barnes & Noble Nook, Kobo eReader, Aluratek Libre, Iliad, Nokia, Blackberry, Hanlin |
| Note | Excellent navigation features are available via Adobe such as bookmarks and a quick access table of contents. Text search is easily accessible. An Adobe DRM-protected file is different than a pdf file in that it uses Adobe DRM (Digital Rights Management) technology, which authors and publishers use to protect their content from illegal online distribution and to set certain privileges such as restrictions on copying and printing. |
Bacterial Population Genetics in Infectious Disease
Chapter One
The Coalescent of Bacterial PopulationsMikkel H. Schierup and Carsten Wiuf
1.1 BACKGROUND AND MOTIVATION
Recent years have seen an explosion in the number of available DNA sequences from many different species. Whereas small genomic regions routinely have been sequenced for more than 20 years and have improved our knowledge of genetic variation at the species and the population levels, new high-throughput techniques have made possible the sequencing of whole genomes and genomic regions for many individuals at an affordable price and in a realistic time frame. This offers unprecedented opportunities for studying genetic variation within and between species and the effects of variation on transcription, regulation, and expression. So, for example, population data sets for bacteria are now expected to consist of full genomes rather than single genes, and the limitations to evolutionary inference are more likely to be found in the analysis rather than in the generation of sequence data (see Chapter 7 of this book).
In the following, we will discuss a mathematical model-the coalescent-that describes the process of generating genetic data, with special reference to bacterial populations. For simplicity, we assume the data are in the form of DNA sequences; however, other forms of genetic markers can likewise be modeled. The sequences (or genes) are all homologous copies of the same genetic region in the genome of a species. The relevance of such a model becomes clear when we want to infer/learn details about the evolutionary processes that generated and shaped a sample of present-day sequences. This process m
...Read full excerpt from Bacterial Population Genetics in Infectious Disease ebook
