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Calcium Binding Proteins
By: Eugene Permyakov , Robert H. KretsingereBook Publisher: John Wiley & Sons
Imprint: Wiley
Format: ePub Encrypted (DRM)
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Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography. The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins. It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.
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| Title of eBook: Calcium Binding Proteins | |
| Release Date: 03-21-2011 | |
| Publisher: Wiley |
This eBook download is available in the following formats:
| Parent title | Calcium Binding Proteins |
|---|---|
| Encrypted (DRM) | Yes |
| SKU | 9780470872383 |
| File size | 7529 |
| Security | n/a |
| Printing | Not allowed |
| Copying | Not allowed |
| Read aloud | No Sys requirements Download reader |
| Devices | Samsung Tablet, Apple Ipad & Iphone, Barnes & Noble Nook, Kobo eReader, Aluratek Libre, Iliad, Nokia, Blackberry, Hanlin |
| Note | Excellent navigation features are available via Adobe such as bookmarks and a quick access table of contents. Text search is easily accessible. An Adobe DRM-protected file is different than a pdf file in that it uses Adobe DRM (Digital Rights Management) technology, which authors and publishers use to protect their content from illegal online distribution and to set certain privileges such as restrictions on copying and printing. |
Calcium Binding Proteins
Chapter One
HISTORICAL PERSPECTIVE
This historical perspective of the functions of calcium in biology lays the foundation for understanding the central role of calcium binding proteins. Ten interrelated themes bring us to about 1970. The successes and frustrations of those concepts help us understand recent decades. For clarity, these themes are each treated chronologically; however, there are myriad, complex interactions among them. Much of that integration is left for subsequent chapters and future research. The themes include biomineralization, coagulation, secondary messengers, colloids, cross-linking, pumps, calcium binding proteins, mitochondria, hormones, and measurements.
1.1. BIOMINERALIZATION
The study of calcium in biology began with bone. "Examination of the red stained human bones, excavated in the cemetery of the Community of the Dead Sea Scrolls at Qumran, showed that the pigmentation was due to alizarin. Its characteristic anatomical location on the extremities and in the medullary cavities was consistent with the location of intravital staining due to a diet containing madder root" (Steckoll et al., 1971). Although we cannot say who first observed this staining by madder root, it provides a fascinating introduction to biomineralization, one of the many functions that involve calcium binding proteins.
In 1581, Lemnius wrote in De Miraculis Occultis Naturae: "So some penetrate into the remotest and farthest parts, and are carried to the Nerves, as Hermodactyls, sweet Mullens, commonly called Palsey-hearb, Madder that colours the bones of the Cattle red, if they chance to eat it green, though they touch n
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