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Radiochemical Syntheses, Radiopharmaceuticals for Positron Emission Tomography
By: Peter J. H. Scott , Brian G. HockleyeBook Publisher: John Wiley & Sons
Imprint: Wiley
Format: ePub Encrypted (DRM)
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The ultimate reference guide to the synthesis of radiopharmaceuticals
The Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory.
Volume 1 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today. It brings together in one complete, self-contained volume a collection of monographs containing a wealth of practical information from across the literature, demonstrating in meticulous detail how to prepare radiopharmaceuticals for positron emission tomography (PET) imaging, especially in tumor studies, cardiology, and neuroscience.
Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals.
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| Title of eBook: Radiochemical Syntheses, Radiopharmaceuticals for Positron Emission Tomography | |
| Release Date: 12-28-2011 | |
| Publisher: Wiley |
This eBook download is available in the following formats:
| Parent title | Radiochemical Syntheses,... |
|---|---|
| Encrypted (DRM) | Yes |
| SKU | 9781118140314 |
| File size | 4086 |
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| Note | Excellent navigation features are available via Adobe such as bookmarks and a quick access table of contents. Text search is easily accessible. An Adobe DRM-protected file is different than a pdf file in that it uses Adobe DRM (Digital Rights Management) technology, which authors and publishers use to protect their content from illegal online distribution and to set certain privileges such as restrictions on copying and printing. |
Radiochemical Syntheses, Radiopharmaceuticals for Positron Emission Tomography
Chapter One
SYNTHESIS OF [18F]-FLUORODEOXYGLUCOSE ([18F]FDG)Michelle L. Richards and Peter J. H. Scott
Department of Radiology, University of Michigan School of Medicine, Ann Arbor, Michigan
1 INTRODUCTION
Positron emission tomographic (PET) imaging provides a noninvasive, accurate diagnostic method of imaging and detecting possible diseases at a cellular, molecular, and tissue level. PET has a proportional relationship between the tissue intensity on the tomographic image and the actual radiopharmaceutical concentration in tissue. [18F]Fluorodeoxyglucose ([18F]FDG) is a glucose analog and is known as the "work horse" of PET simply because of the multiple modalities for application. The implications of abnormal glucose metabolism are vital in evaluating a variety of diseases, and the applications of this positron emitting radiotracer are great. [18F]FDG is preferentially taken up into cells with high metabolic activity by specific glucose transporters (GluT) and phosphorylated by hexokinase. It becomes metabolically trapped in the cell because [18F]FDG-6-phosphate is not a substrate for glucose-6-phosphate isomerase, the enzyme that metabolizes glucose, and therefore cannot be broken down. During radioactive decay, 18F decays to 18O, allowing the decayed product, 2-18O-deoxyglucose-6-phosphate, to enter the normal glucose metabolic pathway.
The first synthesis of [18F]FDG was based on a direct electrophilic substitution reaction by Wolf et al. in 1976. This fluorination reaction by electrophilic substitution refers to the addition of fluor
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