Small to medium enterprises (SMEs) and the role of e-commerce in these organizations continue to change, grow and evolve. Researchers and governments have given rise to the number of strategies, to address the challenges these enterprises face daily in competition with large, global businesses.E-Commerce in Regional Small to Medium Enterprises showcases detailed studies of e-commerce in multiple regional areas, focusing on the role of business size, business sector, market focus, gender of CEO, and education level of the CEO on driving forces for e-commerce adoption. E-Commerce in Regional Small to Medium Enterprises produces new research results to show that even regional SMEs in developed countries have low e-commerce adoption rates, and that strategic alliances by SMEs play a key role in overcoming the low adoption rate. These issues are of ongoing concern to government departments, specifically in Sweden and Australia, and to SME researchers everywhere.