Dr. Rhonda "Ronni" Magnus, a beautiful, ambitious and hard-nosed psychiatrist, is assigned to help a man with amnesia regain his memory. Because of the extraordinary healing powers "John Doe" demonstrates, many believe he is Jesus Christ returned as prophesied in the book of Revelation. Of course, Ronni doesn't buy that explanation at all-at first. In the beginning, she is convinced his amnesia is as false as the psychosomatic "healings" with which people have credited him, and that the fervor of those who seek his attention is nothing more than mass hysteria. However, it's not long before her rigid and strictly scientific worldview is shattered, as she helplessly grows closer to her patient. Before John can either accept or deny the possibility that he is the reincarnated Savior, he needs to know his identity. He also struggles with his growing love for Ronni because it defies his increasing certainty about his destiny. Together, he and Ronni face an even bigger challenge: A wealthy, powerful and resourceful televangelist, Reverend Ethan Stone, believes John poses a real threat to his church. Stone will stop at nothing-including murder-to end that threat.