Bringing together the field's leading authorities, this acclaimed work is widely regarded as the standard reference on depression. The Handbook provides comprehensive coverage of the epidemiology, course, and outcome of depressive disorders; issues in assessment and diagnosis; psychological and biological risk factors; effective approaches to prevention and treatment; and the nature of depression in specific populations. Each chapter offers a definitive statement of current theories, methods, and research findings, while also identifying key questions that remain unanswered.