The beautiful, dangerous, enigmatic Alice returns, and this time she and her fellow survivor Carlos Olivera are running with a pack of humans led by a new ally, Claire Redfield. Together they are cutting through the wastelands of the United States on a long trek to Alaska.

The Hive: a subterranean genetic research facility owned and operated by Umbrella, an immensely powerful corporation with interests in everything from human longevity to biowarfare. With computerized defenses and heavily armed human backup, the Hive is impregnable and invulnerable. Or so Umbrella believes.

But something has gone fatally wrong. The Hive has lost containment of its most lethal and horrific creation: a virus that kills and reanimates human life, reducing the entire facility staff of five hundred men and women to mindless creatures with a single driving force -- hunger. And the key to stopping them rests with one young woman who cannot even remember who she is.

Following the events of Resident Evil: Apocalypse, the beautiful, dangerous, enigmatic Alice returns, and this time she and her fellow survivor Carlos Olivera are running with a pack of humans led by a new ally, Claire Redfield. Together they are cutting through the wastelands of the United States on a long trek to Alaska. Hunted by the minions of the scheming Dr. Isaacs, Alice has zombies hungry for her flesh and the Umbrella Corporation's monstrous lab rats hungry for her blood...while Alice herself hungers only for revenge.