Their baby daughter suffocates in their arms. A mysterious illness takes her life almost instantly. Then, Derek Silverman and his wife find their city littered with dead bodies. No survivors anywhere. For an unknown reason, only they are alive. Using an amateur radio, Derek tries to reach anyone who will answer him. That is his biggest mistake. The perpetrators of the global pandemic receive the radio transmission and dispatch killers. Almost too late, Derek and his wife realize an unknown group caused this and will stop at nothing to kill them too. They are now on the run for their lives in a human-less world.